The effect of excess weight on the lysosome within skeletal muscle
17 September 2024
This study aims to understand how carrying excess weight may affect the size and quality of muscle with our bodies. In addition, we will delve deeper to understand if certain cell pathways which regulate our muscle's size, quality and metabolism are altered in individuals that are carrying excess weight. This will help us understand if we need to target interventions at specific aspects of skeletal muscle during weight loss in order to prevent weight regain.
Requirements
- Male or Female
- Age 18-35yrs
- A Body Mass Index (BMI) of EITHER 18.5-24.9kg/m2 OR >30kg/m2 (you can calculate this by squaring your height in metres and dividing your weight in kg by this number)
- Recreationally active (e.g. not completing a structured exercise programme)
- No Major Metabolic or Neuromuscular Conditions
Keywords
Ethical approval
This study has been given full Ethical Approval by Manchester Metropolitan University's Science and Engineering Research Ethics and Governance Committee (ID 68079)
About the researcher
My name is Nathan Hodson and I am a Senior Lecturer in Musculoskeletal Physiology at Manchester Metropolitan University. My main research interests surround the cell pathways which regulate how our muscle's grow in size and how these may be affected in a variety of scenarios such as increasing age or carrying excess weight. My future aim is to produce interventions which improve muscle size, quality and metabolism in such populations by targeting the cellular pathways which we find to be impaired in these individuals.
